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Jay Patel, PhD

Jay M. Patel, PhD
Professor of Medicine and Pharmacology
Division of Pulmonary, Critical Care & Sleep Medicine
Research Career Scientist
North Florida/South Georgia Veterans Health System

Email: pateljm@medicine.ufl.edu

TEL: 352.273.8737
FAX: 352.379.7421

Degree/Program

Institution

Field/Specialty

PhD Marathwada University, Aurangabad Biochemistry

Research Interests:

  • Development of a rat model of lung transplantation
  • Biology and toxicology of nitric oxide (NO)
  • Regulation of lung endothelial cell NO synthase (eNOS)
  • Pulmonary system toxicology of drugs and environmental chemicals
  • Role of Thioredoxin in Lung Allograft Inju
  • Identifying molecular mechanisms of hypoxia-induced pulmonary hypertension (PH) with specific focus on pericyte/endothelial dynamics in distal capillary remodeling observed in the progression of PH

Professional Societies:

  • Society of Toxicology
  • Society for Free Radical Biology and Medicine
  • Nitric Oxide Society
  • American Society for Pharmacology & Experimental Therapeutics

Honors and Awards:

  • 2003-2005 University of Florida Research Foundation (UFRF) Professorship Award
  • 1995-2000 Member Alcohol and Toxicology Study Section, NIH
  • 1995-1998 Member VA Merit Review Subcommittee for Respiration & Pulmonary Disease

Grants Awarded:

  • Florida Department of Health: Co-Principal Investigator “Tobacco Smoke-Induced Cell Injury in Lung Compartments” 2004-2005
  • NIH: Principal Investigator “NO Toxicity: Redox Regulation of Lung Cell Thioredoxin” 2001 – 2006
  • NIH: Principal Investigator “Calreticulin Regulation of Lung Endothelial Cell NOS” 2001 – 2005
  • VA Merit Review: Principal Investigator “Mechanism of Angiotensin IV-Mediated Regulation of Lung Endothelium NOS” 2000 – 2005
  • NIH: Co-Principal Investigator “Short Term Research Training for Minority Students” 1999-2004

Publications (2004 onwards):

  • “Autoinhibitory Doamin Fragment of Endothelial NOS Enhances Pulmonary Artery Vasorelaxation by NO/cGMP Pathway”.Hanbo Hu, M. Xin, L.L. Belayev, J.L. Zhang, E.R. Block, and J.M. Patel. Am. J. Physdiol Lung Cell Mol. Physiol.286: L1066-L1074, 2004.
  • “Nitric Oxide-Modulated Marker Gene Expression of Signal Transduction Pathways in Lung Endothelial Cells” Liuzhe Li, J.L. Zhang, E.R. Block, and J.M. Patel. Nitric Oxide. In Press.
  • “Nitric Oxide-Induced Persistent Inhibition and Nitrosylation of Active Site Cysteine Residues of Mitochondrial Cytochrome c Oxidase in Lung Endothelial Cells”. J.L. Zhang, Bilian Jin, Liuzhe Li, E.R. Block, and J.M. Patel. Am.J.Physiol Cell Physiol. In Press
  • For a complete list of the publications, visit Pubmed, US National Library of Medicine (NLM)

Please click here for a list of Dr. Patel’s industry relationships.