Yuanqing Lu, MD

Yuanqing Lu, MD
Assistant Scientist
Division of Pulmonary, Critical Care and Sleep Medicine

Email: yqlu@ufl.edu

 

Degree/Program

Institution

Field/Specialty

MD Harbin Medical University, Harbin, P.R. China

Research Interests:

  • Adeno-associated Virus Mediated Gene Therapy
  • Alpha-1 Antitrypsin Deficiency

Publications:

  • Chen MJ, Lu Y, Simpson NE, Beveridge MJ, Elshikha AS, Akbar MA, Tsai HY, Hinske S, Qin J, Grunwitz CR, Chen T, Brantly ML, Song S. In Situ Transplantation of Alginate Bioencapsulated Adipose Tissues Derived Stem Cells (ADSCs) via Hepatic Injection in a Mouse Model. PLoS One. 2015 Sep 15; 10(9).
  • Moldthan HL, Hirko AC, Thinschmidt JS, Grant MB, Li Z, Peris J, Lu Y, Elshikha AS, King MA, Hughes JA, Song S. Alpha 1-Antitrypsin Therapy Mitigated Ischemic Stroke Damage in Rats. J Stroke Cerebrovasc Dis. 2014 May-Jun; 23(5):e355-63.
  • Chen M J, Lu Y, Hamazaki T, Tsai HY, Erger K, Conlon T, Elshikha AS, Li H, Srivastava A, Yao C, Brantly M, Chiodo V, Hauswirth W, Terada N, Song S. Reprogramming adipose tissue-derived mesenchymal stem cells into pluripotent stem cells by a mutant adeno-associated viral vector. Hum Gene Ther Methods. 2014 Feb; 25 (1):72-82.
  • Li H, Zhang B, Lu Y, Jorgensen M, Petersen B, Song S. Adipose Tissue-Derived Mesenchymal Stem Cell-Based Liver Gene Delivery. J Hepatol. 2011 May; 54(5):930-8.
  • Ma H#, Lu Y#, Li H, Campbell-Thompson M, Parker M, Wasserfall C, Haller M, Brantly M, Schatz D, Atkinson M, Song S. Intradermal alpha1-antitrypsin therapy avoids fatal anaphylaxis, prevents type 1 diabetes and reverses HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/20593162″hyperglycaemiaHYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/20593162”HYPERLINK “http://www.ncbi.nlm.nih.gov/pubmed/20593162” in the NOD mouse model of the disease. Diabetologia. 2010 Oct; 53(10):2198-204. (# Equal contribution).
  • Li H, Lu Y, Witek RP, Chang LJ, Campbell-Thompson M, Jorgensen M, Petersen B, Song S. Ex Vivo Transduction and Transplantation of Bone Marrow Cells for Liver Gene Delivery of α1-Antitrypsin. Mol Ther. 2010 Aug; 18(8):1553-8.
  • Grimstein C, Choi YK, Satoh M, Lu Y, Wang X, Campbell-Thompson M, Song S. Combination of alpha-1 antitrypsin and doxycycline suppresses collagen-induced arthritis. J Gene Med.  2010 Jan; 12 (1):35-44.
  • Lu Y, Song S. Distinct immune responses to transgene products from rAAV1 and rAAV8 vectors. 2009 Oct 6; 106(40):17158-62.
  • Lu Y, Parker M, Pileggi A, Zhang B, Choi YK, Molano RD, Wasserfall C, Ricordi C, Inverardi L, Brantly M, Schatz D, Atkinson M, Song S. .Human alpha 1-antitrypsin therapy induces fatal anaphylaxis in non-obese diabetic mice. Clin Exp Immunol. 2008 Oct; 154 (1):15-21.
  • Zhang B, Lu Y, Campbell-Thompson M, Spencer T, Wasserfall C, Atkinson M, Song S. Alpha1-antitrypsin protects beta-cells from apoptosis. Diabetes. 2007 May; 56(5):1316-23.
  • Lu Y, Tang M, Wasserfall C, Kou Z, Campbell-Thompson M, Gardemann T, Crawford J, Atkinson M, Song S.Alpha1-antitrypsin gene therapy modulates cellular immunity and efficiently prevents type 1 diabetes in nonobese diabetic mice. Hum Gene Ther. 2006 Jun; 17(6):625-34.
  • Lu Y, Choi YK, Campbell-Thompson M, Li C, Tang Q, Crawford JM, Flotte TR, Song S. Therapeutic level of functional human alpha 1 antitrypsin (hAAT) secreted from murine muscle transduced by adeno-associated virus (rAAV1) vector. J Gene Med. 2006 Jun; 8(6):730-5.
  • Song S, Witek RP, Lu Y, Choi YK, Zheng D, Jorgensen M, Li C, Flotte TR, Petersen BE. Ex vivo transduced liver progenitor cells as a platform for gene therapy in mice. Hepatology. 2004 Oct; 40 (4):918-24.
  • Song S, Lu Y, Choi YK, Han Y, Tang Q, Zhao G, Berns KI, Flotte TR.DNA-dependent PK inhibits adeno-associated virus DNA integration. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2112-6.