Mark L. Brantly, MD

Mark L. Brantly, MD
Professor of Medicine
Vice Chair of Research, Department of Medicine
Alpha-1 Foundation Research Professor

Brantly Lab


TEL: 352-273-8737




MDUniversity of Florida College of Medicine 
ResidencyEastern Virginia Medical SchoolInternal Medicine
FellowshipNational Institute of Health, Bethesda, MDPulmonary Disease & Critical Care

Clinical Interests:

  • Alpha-1 Antitrypsin Deficiency
  • Alpha-1 Antitrypsin Test
  • Chronic Obstructive Pulmonary Disease

Research Interests:

  • Role of Inflammation in Alpha-1 Antitrypsin Deficiency
  • Chronic Obstructive Pulmonary Disease

Professional Societies:

  • American Thoracic Association
  • American Society of Cell Biology

Honors and Awards:

  • 1995 Alpha1 National Association Award
  • 1998 Alpha1 Foundation Research Professorship

Publications (2004 onwards):

  • M. Brantly, J. Wittes, C. Vogelmeier, R. Hubbard, G. Fells, and R. Crystal. Use of a Highly Purified a1-Antitrypsin Standard to Establish Ranges for the Common Normal and Deficient a1-Antitrypsin Phenotypes. Chest 1991 Sept;100:703-708.
  • Flotte TR, Brantly ML, Spencer LT, Byrne BJ, Spencer CT, Baker DJ, Humphries M. Phase I trial of intramuscular injection of a recombinant adeno-associated virus alpha 1-antitrypsin (rAAV2-CB-hAAT) gene vector to AAT-deficient adults. Human Gene Therapy 2004 Jan; 15:93-128.
  • Strange, C., Dickson, R., Carter, C., Carpenter, M.J., Holladay, B., Lundquist, R., Brantly, M.L. Genetic Testing for Alpha1-Antitrypsin Deficiency. Genetic Testing for Alpha1-Antitrypsin Deficiency. In press Genetics in Medicine 2004.

For a complete list of the publications,
Visit Pubmed, US National Library of Medicine (NLM)


Increased Expression of Alpha-1-Antitrypsin in Expression Vectors through the inclusion of Intron II. Patent Serial Number 08/060,925

Please click here for a list of Dr. Brantly’s industry relationships.