Alpha-1 Antitrypsin Deficiency, LAM, & Rare Lung Diseases

Alpha-1 Antitrypsin Deficiency

  • Alpha-1 Antitrypsin Deficiency (Alpha-1) is the most common inherited cause of COPD affecting 1 in every 10 individual with COPD. Alpha-1 can lead to lung destruction and liver diseases (cirrhosis). Some of the most common Alpha-1 symptoms are shortness of breath, wheezing, recurring chest colds, chronic cough and sputum production. Alpha-1 can be detected by a simple blood test through free testing program sponsored by The Alpha One Foundation. For more details on this, contact 1800-559-570. For further details about the Alpha one program, please visit:

Lymphangioleiomyomatosis (LAM)

  • LAM is a rare cystic lung disease that almost always affects young females. It may occur for no reason (sporadic) or be associated with the disease Tuberous Sclerosis Complex (TSC). Patients often present with shortness of breath, cough, or chest pain from a lung collapse. Diagnosis can be made based on imaging testing and special blood test. Rarely, patients may need a lung biopsy to confirm the diagnosis. The LAM clinic at UF Shands is accredited by the LAM Foundation, for more information on LAM please visit:

Pulmonary Alveolar Proteinosis (PAP)

  • PAP is a rare lung disease where there is build-up of proteins and other substances in the lungs resulting in inability to exchange oxygen efficiently with the blood. Patients develop symptoms of shortness of breath, chronic cough and recurrent infections. Diagnosis can be made with a special blood test. Symptomatic patients may need to have their lung washed to clear out the proteins and other substances, a procedure called whole lung lavage. For more information on PAP please visit: https://www.papfoundation/org

Other Rare Lung Diseases

  • Our Clinic also specializes in diagnosing and treating patients with other forms of rare lung diseases such as Pulmonary, Langerhans Cell Histiocytosis (PLCH), Hermansky-Pudlak Syndrome (HPS), and other rare lung diseases.

Location & Clinic Hours

  • The Alpha-1, LAM, and Rare Lung Disease Clinic is located in the Internal Medicine and Medical Specialties Clinic, which is on the third floor of the Shands Medical Plaza. The clinics are held on the second and fourth Wednesdays of every month from 1:00 pm to 5:00 pm.

How to make an Appointment

  • New Patients as well as Returning Patients should call 352.273.8740.

Medical Professionals