Alpha-1 antitrypsin deficiency
Khodayari Lab
Research
Nazli Khodayari, PhD
Assistant Professor of Medicine
Nazli.khodayari@medicine.ufl.edu
Overview
Dr. Khodayari’s lab focuses on understanding the mechanisms of tissue injury mediated by Alpha-1 Antitrypsin Deficiency, a genetic disorder that impacts both pulmonary and hepatic health. They investigate how the protease-antiprotease imbalance in Alpha-1 Antitrypsin Deficiency contributes to chronic inflammation, impaired tissue repair, and fibrosis in multiple organs. By studying the cellular and molecular pathways underlying these processes, the lab aims to identify novel therapeutic strategies to mitigate tissue damage and improve outcomes for individuals affected by Alpha-1 Antitrypsin Deficiency.
Focus Areas
- Alpha-1 Antitrypsin Mediated Liver Injury
- Liver Proteostasis
- Alpha-1 Antitrypsin Mediated inflammation
- Neutrophils Biology
- Metabolism Dysfunction Associated with Alpha-1 Antitrypsin
Lab Staff
Laboratory Manager
Regina Oshins
- If you are interested in volunteering, please reach out to Dr. Khodayari via email.
Publication Highlights
- Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway
- Lung Inflammation in alpha-1-antitrypsin deficient individuals with normal lung function
- Alpha-1 antitrypsin deficient individuals have circulating extracellular vesicles with profibrogenic cargo
- Modulation of calreticulin expression reveals a novel exosome-mediated mechanism of Z variant α1-antitrypsin disposal
- Pioglitazone reduces hepatic α-1 antitrypsin accumulation through autophagy and AMPK activation in α-1 antitrypsin-deficient mice
For more PI Publications please follow the links below