Schaller Lab

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The interests of the Schaller lab include:

1) Host/pathogen interactions in the lung in the context of viral or bacterial infections, including SARS-CoV-2 and M. tuberculosis.

2) The genesis and maintenance of granulomas in the context of both M. tuberculosis infection and the disease sarcoidosis, for which the causative agent is unknown.

3) The use of novel culture systems to study these diseases, including immune cell interactions with tissue.

4) The contribution of chromatin modifications to immune cell phenotype in the context of pathogen exposure.

Lab Faculty and Staff

Assistant Professor of Medicine

Matthew Schaller

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laboratory technician

Zadia Dupee

Zadia Dupee

graduate assistant

Nickolas Diodati

Nickolas Diodati

RESEARCH POST-DOCTORAL

Felipe Lima

Felipe Lima

Publication HIGHLIGHTS

  • Ting H-A, Schaller MA, Nagata DE de A, Rasky AJ, Maillard IP, Lukacs NW. Notch Ligand Delta-like 4 Promotes Regulatory T Cell Identity in Pulmonary Viral Infection. The Journal of Immunology. 2017 Feb 15;198(4):1492–1502. PMID: 28077598
  • Bermick JR, Lambrecht NJ, denDekker AD, Kunkel SL, Lukacs NW, Hogaboam CM, Schaller MA. Neonatal monocytes exhibit a unique histone modification landscape. Clin Epigenetics. 2016;8:99. PMCID: PMC5028999
  • Schaller M, Ito T, Allen RM, Kroetz D, Kittan N, Ptaschinski C, Cavassani K, Carson WF, Godessart N, Grembecka J, Cierpicki T, Dou Y, Kunkel SL. Epigenetic regulation of IL-12-dependent T cell proliferation. J Leukoc Biol. 2015 Oct;98(4):601–613. PMCID: PMC4763868
  • Schaller MA, Allen RM, Kimura S, Day CL, Kunkel SL. Systemic Expression of Notch Ligand Delta-Like 4 during Mycobacterial Infection Alters the T Cell Immune Response. Front Immunol. 2016;7:527. PMCID: PMC5121470

A full list of peer-reviewed publications can be viewed here:

https://www.ncbi.nlm.nih.gov/sites/myncbi/matthew.schaller.1/bibliography/40022782/public/