Saltini Lab


Cesare Saltini, Research Professor, Pulmonary Critical Care MedicineCesare Saltini, MBBS (MD)
Research Professor
Division of Pulmonary, Critical Care and Sleep Medicine


TEL: 352.627.9224
FAX: 352.392.7088







  • Alana Erickson, Research Student Assistant

Research Interests

  • Pulmonary Fibrosis

Grant Support

  • University of Florida, Gatorade Trust, University of Florida, Department of Medicine. “Unrestrained Pro-Inflammatory Alveolar Macrophage in Idiopathic Pulmonary Fibrosis” 2017.


  • Use of amino acid sequences from Mycobacterium tuberculosis for the diagnosis and prevention of tuberculosis infection” , no. PCT/IT2011/000266


  • Saltini C., Winestock K., Kirby M., Pinkston P., Crystal R.G. Maintenance of alveolitis in patients with chronic beryllium disease by berylli-um-specific helper T-cells. N. Engl. J. Med. 1989; 320: 1103-1109 PubMed PMID: 2469014.
  • Saltini C, Kirby M, Trapnell BC, Tamura N, Crystal RG. Biased accumulation of T lymphocytes with “memory”-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung. J Exp Med. 1990 Apr 1;171(4):1123-40. PubMed PMID: 2139099; PubMed Central PMCID: PMC2187829.
  • Saltini C., Amicosante M., Girardi E., Antonucci G., Ippolito G., Ameglio F., Monno L., Congedo P., Angarno G., Babudieri S., Guaraldi G., Visco G., Piccolella E., Pallotta G., Paone G., Bisetti A., Early abnormalities of the antibody response against M.Tuberculosis in HIV infection. J. Infect. Dis., 1993;168: 1409-1414 PubMed PMID: 8105536.
  • Richeldi L., Sorrentino R., Saltini C. HLA-DPB1 Glutamate 69: a genetic marker of beryllium disease. Science, 1993, 262:242-244.
  • Amicosante M, Barnini S, Corsini V, Paone G, Read CA Jr, Tartoni PL, Singh M, Albera C, Bisetti A, Senesi S, Campa M., Saltini C. Evaluation of a novel tuberculosis complex-specific 34 kDa protein in the serological diagnosis of tuberculosis. Eur Respir J. 1995 Dec;8(12):2008-14. PubMed PMID: 8666094.
  • Richeldi L, Kreiss K, Mroz MM, Zhen B, Tartoni P, Saltini C. Interaction of genetic and exposure factors in the prevalence of berylliosis. Am J Ind Med. 1997 Oct;32(4):337-40. PubMed PMID: 9258386.
  • Saltini C, Pallante M, Puxeddu E, Contini S, Voorter CE, Drent M, Amicosante M. M. avium binding to HLA-DR expressed alleles in silico: a model of phenotypic susceptibility to sarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2008 Dec;25(2):100-16. PubMed PMID: 19382529.
  • Amicosante M, Beretta F, Dweick R, Saltini C.  Role of high-affinity HLA-DP specific CLIP-derived peptides in beryllium binding to the HLA-DPGlu69 berylliosis-associated molecules and presentation to beryllium-sensitized T cells. IMMUNOLOGY, 2009; 128; p. 462-470 PubMed PMID: 19191908.
  • Ora J, Calzetta L, Pezzuto G, Senis L, Paone G, Mari A, Portalone S, Rogliani P, Puxeddu E, Saltini C. A 6MWT index to predict O2 flow correcting exercise induced SpO2 desaturation in ILD. Respir Med. 2013 Dec;107(12):2014-21. PubMed PMID: 24161677.
  • Spitalieri P, Quitadamo MC, Orlandi A, Guerra L, Giardina E, Casavola V, Novelli G, Saltini C, Sangiuolo F. Rescue of murine silica-induced lung injury and fibrosis by human embryonic stem cells. Eur Respir J. 2012 Feb;39(2):446-57. PubMed PMID: 21719484
  • Sangiuolo F., E. Puxeddu, G. Pezzuto, F. Cavalli, G. Longo, A. Co-mandini, D. Di Pierro, M. Pallante, G. Sergiacomi, G. Simonetti, M. Zompatori, A. Orlandi, A. Magrini, M. Amicosante, F. Mariani, M. Losi, D. Fraboni, A. Bisetti, C. Saltini. HFE gene variants and iron induced O2 radical generation in idiopathic pulmonary fibrosis. Eur Respir J. 2015:  Feb;45(2):483-90. PubMed PMID: 25504993
  • Lee J. , Arisi I., Puxeddu E., Mramba L., Amicosante M., Swaisgood CM., Pallante M.,  Brantly ML., Saltini C. Alveolar macrophages in Idiopathic Pulmonary Fibrosis express a complex pro-repair, pro-inflammatory, angiogenic activation pattern, likely associated with iron accumulation. PLOS1 submitted