division of pulmonary, critical care & Sleep medicine
Jin Lab
Research
Lei Jin, PhD, MSC
Associate Professor of Medicine (Tenured)
lei.jin@medicine.ufl.edu
Overview
The Jin Lab studies immune tolerance in the lungs that protects against chronic lung inflammation with a focus on functionally distinct lung dendritic cell subsets. They also study functionally distinct and common human MPYS/TMEM173/STING genotypes in human health and medicine.
Focus Areas
- Lung Dendritic Cells
- Chronic Respiratory Diseases
- Common Human STING Genotypes
- Alzheimer’s Disease
- SAVI (STING-Associated Vasculopathy with Onset in Infancy)
Lab Staff
Biological Scientist I
Alexandra Aybar-Torres
ops laboratory technician
Mollie Usher
- If you are interested in volunteering, please reach out to Dr. Lei Jin via email.
Publication Highlights
- Identification of common human TMEM173 genotypes associated with Alzheimer’s disease
- The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
- MPYS Modulates Fatty Acid Metabolism and Immune Tolerance at Homeostasis Independent of Type I IFNs
- The Common R71H-G230A-R293Q Human TMEM173 Is a Null Allele
- Identification and characterization of a loss-of-function human MPYS variant
- In vivo reprogramming of pathogenic lung TNFR2+ cDC2s by IFNβ inhibits HDM-induced asthma
- Monocyte-Derived Dendritic Cells (moDCs) Differentiate into Bcl6+ Mature moDCs to Promote Cyclic di-GMP Vaccine Adjuvant-Induced Memory TH Cells in the Lung
- Lung IFNAR1hi TNFR2+ cDC2 promotes lung regulatory T cells induction and maintains lung mucosal tolerance at steady state
- Immature lung TNFR2– conventional DC 2 subpopulation activates moDCs to promote cyclic di-GMP mucosal adjuvant responses in vivo
- MPYS/STING-mediated TNF-α, not type I IFN, is essential for the mucosal adjuvant activity of (3′-5′)-cyclic-di-guanosine-monophosphate in vivo
For more PI Publications please follow the links below
