Alpha-1 Antitrypsin Deficiency
Serban Lab
Research
Karina Serban, MD
Associate Professor of Medicine
karina.serban@medicine.ufl.edu
Overview
The Serban Lab uses 2D and 3D cell culture models, transgenic mice exposed to cigarette smoke, and patient-derived samples to investigate the pathobiology and novel biomarkers in individuals with Chronic Obstructive Pulmonary Disease (COPD), emphysema, and Alpha-1 antitrypsin deficiency. Dr. Serban’s current projects focus on innate immune responses in the lungs of COPD and Alpha-1 individuals, with emphasis on the complement cascade and the crosstalk between the airway macrophages and lung epithelium during injury and repair.
Focus Areas
- Alpha-1 Antitrypsin Deficiency
- COPD
- Alveolar Epithelial Cells Type 2
- Mitochondrial Metabolism
- Complement Cascade
Lab Faculty and Staff
ASSISTANT DIRECTOR, ALPHA-1 PROGRAM
Tammy Flagg
senior research scientist
Indu Tripathi
Post Doctoral Associate
Maria Magallon
post doctoral associate
Aparna Venugopalan
PhD student
Lan Nguyen
Laboratory Technician II
Aidan Griffin
clinical research coordinator III
Brandi Lattinville
Emeritus Professor of Medicine
Mark L. Brantly
- The Serban Lab welcomes inquiries from post-doctoral fellows and graduate students interested in lung Alpha-1 Antitrypsin Deficiency and COPD translational and bench research. You can submit your inquiry via email to the PI, Dr. Karina Serban.
Publication Highlights
- Lectin Complement Pathway in Emphysema
- Alpha-1 antitrypsin inhibits fractalkine-mediated monocyte-lung endothelial cell interactions
- Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency
- Transitional human alveolar type II epithelial cells suppress extracellular matrix and growth factor gene expression in lung fibroblasts
- Influenza virus infection increases ACE2 expression and shedding in human small airway epithelial cells
- Use of the Wnt/β-catenin Activator Lithium Is Associated with Less Emphysema
- Ceramide and sphingosine-1 phosphate in COPD lungs
- Marked elevations in lung and plasma ceramide in COVID-19 linked to microvascular injury
- Alpha-1 Antitrypsin Investigations Using Animal Models of Emphysema
- α1-Antitrypsin Binds to the Glucocorticoid Receptor with Anti-Inflammatory and Antimycobacterial Significance in Macrophages
For more PI Publications please follow the links below
